1. Absolute mortality difference Change in LVEF from baseline
Absolute mortality difference and LVEF changes in patients with sinus rhythm (beta-blockers vs. placebo)
LVEF at baseline
Absolute mortality difference
Change in LVEF from baseline
<20%
-6.9%
(95% CI: -10.3% to -3.5%; N=2552)
+4.7%
(SE: 0.5%; N=1106)
20-25%
-3.9%
(95% CI: -6.3% to -1.6%; N=3885)
+4.0%
(SE: 0.5%; N=1068)
26-34%
-3.2%
(95% CI: -5.1% to -1.4%; N=5076)
+4.2%
(SE: 0.5%; N=1600)
35-39%
-3.4%
(95% CI: -6.1% to -0.7%; N=1929)
+4.9%
(SE: 0.9%; N=375)
40-49%
-5.2%
(95% CI: -10.0% to -0.3%; N=575)
+1.9%
(SE: 1.1%; N=251)
≥50%
+2.3%
(95% CI: -5.3% to +9.9%; N=244)
+0.1%
(SE: 1.2%; N=201)
LVEF: left ventricular ejection fraction; CI: confidence interval;
SE: standard error of the mean difference
Reference: Cleland JGF, et al. EHJ 2018;39:26–35