1. Market America World Conference – February 2016
by Dr. Steven Lamm
&

3. Learn How to…
…Defend Your Health

4. Isotonix®

5. HEART
MUSCLES
Isotonix®
BRAIN
EYES
VEINS
SKIN

6. Build mass…
…but don’t lose it!

7. NEW STUDY : Muscle Function / Sarcopenia
Defend Your Muscles
NEW STUDY : Muscle Function / Sarcopenia
64 subjects with loss of muscle mass with age (sarcopenia) 
70-78 years of age with high oxidative stress (>320 Carr U)
2 months
Belcaro G. et al, in submission

8. Pycnogenol® improves muscular function
% improvement in muscular function in 8 weeks * * * * * *
*p<0.05 vs baseline and controls
Belcaro G. et al, in submission

9. Pycnogenol® decreases proteinuria*
*a marker of muscular loss in urine
Control Group *
Pycnogenol®
*p<0.05 vs baseline and controls
Belcaro G. et al, in submission

10. Defend Your Brain Clinical Study with 77 subjects
55-70 years of age with high oxidative stress
Belcaro G. et al, J Neurosurg Sci submitted

11. Pycnogenol® improves cognitive functions
% improvement of cognitive functions (VASL) after 12 months * * * * * * *
*p<0.05
Belcaro G. et al, J Neurosurg Sci submitted

12. Defend Your Eyes Clinical Study with 77 subjects 9 months
Aim prevention of a new retinal vein thrombosis episode
Rodriguez, P., et al. (2015). " Panminerva Med 57(3):

13. Pycnogenol® and retinal vein thrombosis*
*p<0.05
Rodriguez, P., et al. (2015). " Panminerva Med 57(3):

14. Pycnogenol® effect on retinal edema*
*p<0.05
Rodriguez, P., et al. (2015). " Panminerva Med 57(3):

15. Pycnogenol® effect on visual acuity
20/25 *
20/32
20/40
*p<0.05
Rodriguez, P., et al. (2015). " Panminerva Med 57(3):

16. Defend Your Skin Clinical Study with 20 menopausal women
Aged years,
Skin type II or III
Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1):

17. Pycnogenol® effects on melanogenesis
start
12 weeks
start
12 weeks
20 healthy postmenopausal women
75 mg/day Pycnogenol for 12 weeks
Pycnogenol significantly improved hydration and elasticity of skin.
These effects were most pronounced in women presenting with dry skin conditions prior to the start of supplementation.
significant increase in the mRNA expression of hyaluronic acid synthase-1 (HAS- 1), an enzyme critically involved in the synthesis of hyaluronic acid, and a noticeable increase in gene expression involved in collagen de novo synthesis
UVA-1 radiation 100 J/cm2 (area of 4 cm2)
Treatment regimen: 75 mg oral Pycnogenol® for 12 weeks
Biopsies at start and at 12 weeks before and after UV radiation
mRNA expression of MITF, TRP1, MART, Tyrosinase & Loricrin
Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1):

18. Pycnogenol® inhibits UVA induced hyperpigmentation
-75%
-51%
-67%
-67%
Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1):

19. Pycnogenol® increases gene expression of loricrin
Loricrin, a major component of the cornified cell in the stratum corneum accounts for much of cornified envelope mechanical resistance.
X 2.5
P=0.017
Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1):

20. Pycnogenol® compared to European OTC for venous health

21. Example : Chronic Venous Insufficiency
Pycnogenol® vs. Antistax®
Ankle
Swelling
Resting
Flux
Ankle
Circumference
Pain
Edema
Compression
-0%
-0%
-2%
-3%
-6%
-11%
-20%
-27%
-41%
-48%
-48%
-86%
*p<0.05 vs baseline, N=166, Antistax® 720 mg/day, Pycnogenol® 100mg/day
Belcaro, G. (2015). " International Journal of Angiology.

22. Pycnogenol® more effective than Antistax®
Signs and symptoms of CVI
Edema
Capillary filtration
Blood flow
Microcirculation
Oxidative stress
And more
Belcaro, G. (2015). " International Journal of Angiology.

23. Isotonix® Helps Defend Your Health

24. Defend Your Health

25. Thank you HORPHAG RESEARCH
PO Box 80 Avenue Louis-Casaï 71 CH-1216 Cointrin / GENEVA Switzerland Tel +41 (0) Fax +41 (0)