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Schematic representation of an MR analysis.

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Presentation on theme: "Schematic representation of an MR analysis."— Presentation transcript:

1 Schematic representation of an MR analysis.
Schematic representation of an MR analysis. MR can be used to test the hypothesis that exposure (childhood BMI) causes outcomes (cardiometabolic diseases and related traits). Three assumptions of MR are as follows: 1) genetic variants must be associated with childhood BMI, 2) genetic variants must not be associated with confounders, and 3) genetic variants must influence cardiometabolic diseases and related traits only through childhood BMI, not through other pathways. GRS, genetic risk score. Tingting Geng et al. Dia Care 2018;41: ©2018 by American Diabetes Association

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