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Mohamad Irani, M.D., Zaher Merhi, M.D.  Fertility and Sterility 

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Presentation on theme: "Mohamad Irani, M.D., Zaher Merhi, M.D.  Fertility and Sterility "— Presentation transcript:

1 Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review 
Mohamad Irani, M.D., Zaher Merhi, M.D.  Fertility and Sterility  Volume 102, Issue 2, Pages e3 (August 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Effect of vitamin D on serum antimüllerian hormone (AMH) and AMH/AMH receptor II gene expression. PCOS = polycystic ovary syndrome. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Role of vitamin D in human luteinized granulosa cells. Vitamin D down-regulates FSH receptor (FSHR) and antimüllerian hormone (AMH) receptor II (AMHR-II) mRNA levels. It also decreases Smad 1/5/8 phosphorylation and nuclear translocation. Additionally, vitamin D induces 3-beta-hydroxysteroid dehydrogenase (3β-HSD) mRNA expression and increases progesterone production and release. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Association of vitamin D deficiency with factors related to ovulatory dysfunction in polycystic ovary syndrome (PCOS). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

5 Supplemental Figure 1 Summary of the origin and function of vitamin D. Reprinted by permission from Dr. Frauke von Versen–Höynck: Grundmann M, von Versen–Höynck F. Vitamin D—roles in women's reproductive health? Reprod Biol Endocrinol 2011; 9:146. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

6 Supplemental Figure 2 Data search strategy.
Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

7 Supplemental Figure 3 Antimüllerian hormone (AMH) inhibits FSH-induced follicular growth in a paracrine fashion. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

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