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The clomiphene citrate challenge test for the prediction of poor ovarian response and nonpregnancy in patients undergoing in vitro fertilization: a systematic.

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Presentation on theme: "The clomiphene citrate challenge test for the prediction of poor ovarian response and nonpregnancy in patients undergoing in vitro fertilization: a systematic."— Presentation transcript:

1 The clomiphene citrate challenge test for the prediction of poor ovarian response and nonpregnancy in patients undergoing in vitro fertilization: a systematic review  Dave J. Hendriks, Ph.D., Ben-Willem J. Mol, Ph.D., Laszlo F.J.M.M. Bancsi, Ph.D., Egbert R. te Velde, Ph.D., Frank J.M. Broekmans, Ph.D.  Fertility and Sterility  Volume 86, Issue 4, Pages (October 2006) DOI: /j.fertnstert Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Sensitivity and specificity pairs from studies in which data on poor response prediction are available. Because of heterogeneity among studies, no estimated summary receiver operating characteristics point or curve could be constructed. (Inset) Point estimates (with confidence limits) of the diagnostic odds ratio (DOR). Values lack homogeneity (P=.001). Hendriks. CCCT in IVF patients: a systematic review. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Receiver operating characteristics space comparison of basal FSH (open circles) and the full CCCT (solid circles) for four studies in which both tests were carried out. Arrows indicate the shift in sensitivity and specificity for the prediction of poor response if basal FSH is replaced by the CCCT. Hendriks. CCCT in IVF patients: a systematic review. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 Sensitivity and specificity pairs from studies in which data on pregnancy prediction are available. Due to heterogeneity among studies no estimated summary receiver operating characteristics point of curve could be constructed. (Inset) Point estimates (with confidence limits) of the diagnostic odds ratio (DOR). Values lack homogeneity (P=.036). Hendriks. CCCT in IVF patients: a systematic review. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

5 FIGURE 4 Receiver operating characteristics space comparison of basal FSH (open circles) and the full CCCT (solid circles) for six studies in which both tests were carried out. Arrows indicate the shift in sensitivity and specificity for the prediction of nonpregnancy if basal FSH is replaced by the CCCT. Hendriks. CCCT in IVF patients: a systematic review. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions


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