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Reduced copy number of DAZ genes in subfertile and infertile men

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Presentation on theme: "Reduced copy number of DAZ genes in subfertile and infertile men"— Presentation transcript:

1 Reduced copy number of DAZ genes in subfertile and infertile men
Jan W.A de Vries, M.Sc., Mariëtte J.V Hoffer, Ph.D., Sjoerd Repping, M.Sc., Jan M.N Hoovers, Ph.D., Nico J Leschot, M.D., Ph.D., Fulco van der Veen, M.D., Ph.D.  Fertility and Sterility  Volume 77, Issue 1, Pages (January 2002) DOI: /S (01)

2 FIGURE 1 Schematic drawing of the two DAZ gene clusters. Sequence family variants (SFVs) between the four different genes. sY587 distinguishes between clusters 1 and 2, sY581 distinguishes between the genes within the clusters, and sY586 distinguishes between DAZ2 and the other three genes. The location of the three cosmids used for fluorescence in situ hybridization is also shown. de Vries.Reduced DAZ gene copy number.Fertil Steril 2002. Fertility and Sterility  , 68-75DOI: ( /S (01) )

3 FIGURE 2 Results of fiber fluorescence in situ hybridization on DNA from patient 4937, who had an AZFb deletion and a normal DAZ gene cluster. Red signal, 18E8; green signal, 63C9. de Vries.Reduced DAZ gene copy number.Fertil Steril 2002. Fertility and Sterility  , 68-75DOI: ( /S (01) )


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