1. Big Q: How can we use genetics to study human inheritance?
Human Heredity
Big Q: How can we use genetics to study human inheritance?

2. Engage - Untamed Science
Why is colorblindness more likely to affect men than women?
What does it mean to be sex-linked?

3. Explain - Karyotypes
Karyotype - shows the complete diploid set of chromosomes grouped together in pairs and arranged in order of decreasing size.
Shows:
1. Autosomes - body chromosomes (22 pairs)
2. Sex Chromosomes - X and Y (1 pair)
genome - a full set of genetic information

4. Explore - Multiple Alleles
Look at the chart and explain how individuals are able to have more than one gene for a trait.
contain antigens:
A - antigen A
B - antigen B
AB - antigens AB
O - no antigens

5. Explain - Sex Linked
Sex-Linked Genes - can only be carried on sex chromosomes

6. Elaborate - How is Color Blindness transmitted?
Investigate how genes are transmitted when they are sex linked.
****Answer all questions on your quick lab worksheet

7. Explain - Human Pedigree
Pedigree Chart - shows the presence or absence of a trait throughout a family history

8. Explore - Genetic Disorders
Cystic Fibrosis - deletion of three bases for the CFTR protein preventing the lungs from absorbing chlorine ions.
Symptoms - serious digestive problems and thick heavy mucus that clogs breathing passageways

9. Explain - Genetic Disorders
Sickle Cell Disease - defective allele for beta-globin preventing normal carry of red blood cells
Symptoms - abnormal shape or number of blood cells, blood clots, difficulty breathing, lack of energy, iron deficiency

10. Elaborate - Malaria Study
Investigate the geography of malaria to see how this disease is affected by sickle cell anemia
***Answer questions on your Quick Lab Worksheet

11. Explain - Genetic Disorders
Huntington’s Disease - a long repeat of three base pairs causes a protein in the brain to form incorrectly
Symptoms - mental deterioration and uncontrollable movements

12. Explain - genetic Disorders
Nondisjunction - chromosomes do not separate correctly during meiosis
Types:
1. Down Syndrome - Trisomy 21, three copies
2. Klinefelter’s Syndrome - XXY
3. Turner Syndrom - X

13. Explain - Studying DNA
Cutting DNA - restriction enzymes can make precise cuts in DNA
Separating DNA - gel electrophoresis separates DNA based on size

14. Evaluate - Genetic Disorders
Research and create an information pamphlet about a genetic disorder.
1. Sickle Cell Anemia
2. Hemophilia
3. Cystic Fibrosis
4. Huntington’s Disease
5. ALS Disease
6. PKU
7. Tourette’s Syndrome
8. Muscular Dystrophy
9. Retinitis Pigmentosa
10. Tay Sach’s Diseas
11. Fragile X Syndrome
12. Angelman Syndrome
13. Patau’s Syndrome
14. Edward Syndrome
Include:
Type of mutation
Symptoms
Complications
Description of mutation