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Comparison of ternary TCR-lipid-CD1 complex structures.

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Presentation on theme: "Comparison of ternary TCR-lipid-CD1 complex structures."— Presentation transcript:

1 Comparison of ternary TCR-lipid-CD1 complex structures.
Comparison of ternary TCR-lipid-CD1 complex structures. Crystal structures of self-lipid presentation by CD1b (PG90 TCR-CD1b-PG) (A, D, and G) and CD1a [BK6 TCR–CD1a–lysophosphatidylcholine (LPC)] (B, E, and H) (29) and foreign antigen presentation by CD1b (GEM42 TCR-CD1b-GMM) (C, F, and I) (16). Blue and purple spheres, representing the center of mass of TCR α and β, respectively (D to F), footprints (red, bottom panels), and extent of antigen interaction (cyan), with antigen atoms not involved in the interaction in black (G to I). Ternary complexes (A to C) are shown in ribbon diagrams and bound lipid antigens as spheres. Blue, scaffold lipids; dark green, PG; orange, LPC; yellow, GMM. Adam Shahine et al. Sci. Immunol. 2017;2:eaao1384 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Comparison of ternary TCR-lipid-CD1 complex structures.

Comparison of ternary TCR-lipid-CD1 complex structures.
The functional and structural basis of phospholipid recognition by the PG90 TCR. The functional and structural basis of phospholipid recognition by the.

The functional and structural basis of phospholipid recognition by the PG90 TCR. The functional and structural basis of phospholipid recognition by the.
Crystal structure of HCMV Pentamer.

Crystal structure of HCMV Pentamer.
Docking footprint of PG90 TCR on CD1b-PG.

Docking footprint of PG90 TCR on CD1b-PG.
TCRs bind to CD1b-PG complexes formed in cells.

TCRs bind to CD1b-PG complexes formed in cells.
Fig. 3 FM MnBi2Te4 bulk. FM MnBi2Te4 bulk. Crystal structure (A) and band structure (B) of the FM bulk. (C) Zoom-in band structures along the out-of-plane.

Fig. 3 FM MnBi2Te4 bulk. FM MnBi2Te4 bulk. Crystal structure (A) and band structure (B) of the FM bulk. (C) Zoom-in band structures along the out-of-plane.
Crystal structures of RSV G-antibody complexes.

Crystal structures of RSV G-antibody complexes.
Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,
Fig. 4 Power and wavelet spectra of benthic δ18O.

Fig. 4 Power and wavelet spectra of benthic δ18O.
Fig. 4 Aβ16–22 fibrils increase the aggregation rate of Aβ40 to a greater extent than Aβ16–22 monomers. Aβ16–22 fibrils increase the aggregation rate of.

Fig. 4 Aβ16–22 fibrils increase the aggregation rate of Aβ40 to a greater extent than Aβ16–22 monomers. Aβ16–22 fibrils increase the aggregation rate of.
Unique Fc functional profiling of HIV-specific Abs from neutralizers.

Unique Fc functional profiling of HIV-specific Abs from neutralizers.
Fig. 1 Map of water stress and shale plays.

Fig. 1 Map of water stress and shale plays.
Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.
Sequence conservation within antigenic sites γ1 and γ2, atomic interactions within the RSV G CCD, and model of RSV G glycoprotein. Sequence conservation.

Sequence conservation within antigenic sites γ1 and γ2, atomic interactions within the RSV G CCD, and model of RSV G glycoprotein. Sequence conservation.
Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.
HT synthesis of boronic acids using the building block approach

HT synthesis of boronic acids using the building block approach
Fig. 6 Comparison of properties of water models.

Fig. 6 Comparison of properties of water models.
Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique ions. Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique.

Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique ions. Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique.
Fig. 1 Experimental apparatus used to train and test free-flying bees on their capacity to learn addition and subtraction. Experimental apparatus used.

Fig. 1 Experimental apparatus used to train and test free-flying bees on their capacity to learn addition and subtraction. Experimental apparatus used.
Fig. 3 Rotation experiment, setup.

Fig. 3 Rotation experiment, setup.

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