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Grid Cells and Neural Coding in High-End Cortices

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Presentation on theme: "Grid Cells and Neural Coding in High-End Cortices"— Presentation transcript:

1 Grid Cells and Neural Coding in High-End Cortices
Edvard I. Moser, May-Britt Moser  Neuron  Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Hierarchical Connectivity Map of the Cortex
Visual input is shown at the bottom (RGC, retinal ganglion cells; LGN, lateral geniculate nucleus) and entorhinal cortex (ER) and hippocampus (HC) at the top. One of the goals of modern neuroscience is to understand pattern formation in high-end cortices such as the entorhinal cortex and the hippocampus. Adapted, with permission, from Felleman and Van Essen (1991). Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

3 Figure 2 A Grid Cell from the Medial Entorhinal Cortex of the Rat Brain The gray trace is the trajectory of a rat that is foraging in a 2.2 m wide enclosure. Spike locations of the grid cell are superimposed on the track. Each black dot corresponds to one spike. Data were recorded by Kristian Frøland. Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

4 Figure 3 Modular Organization of Grid Cells
Grid spacing is shown as a function of position along the entorhinal dorsoventral axis. Each dot corresponds to one cell. Cells on different tetrodes (TT) are shown in separate diagrams. Note stepwise increases in grid spacing. Up to four or five steps were identified in individual animals, each corresponding to a separate module. Modules differed on multiple parameters, including grid scale, grid orientation, grid symmetry, and theta modulation. Adapted from Stensola et al. (2012). Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

5 Figure 4 Spontaneous Formation of Hexagonal Firing Patterns in a Model of Grid Cells A hexagonal grid forms spontaneously on a two-dimensional lattice of stellate cells with all-or-none inhibitory interconnections. Each pixel corresponds to one cell in the lattice. Neurons are arranged according to the x-y locations of their grid fields. Rings indicate the area of inhibition around two example cells (crosses). Firing rate is color coded as shown in the scale bar. Reproduced from Couey et al. (2013). Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions


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