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X-ray radiographic images showing structural alterations of the joints that are most commonly affected by OA. (A) Normal and (A′) severely affected joint of the hip, characterized by joint space narrowing (arrow) and osteophyte (bony outgrowth) formation (arrowheads). X-ray radiographic images showing structural alterations of the joints that are most commonly affected by OA. (A) Normal and (A′) severely affected joint of the hip, characterized by joint space narrowing (arrow) and osteophyte (bony outgrowth) formation (arrowheads). (B) Normal and (B′) severely affected joint of the knee, showing alterations in the medial compartment, with almost complete disappearance of the joint space (arrow) and lateral involvement. (C) Normal and (C′) severely affected joint of the hand. The panel shows the distal interphalangeal joint with disappearance of the joint space and small osteophyte formation (arrowheads). Sarah Thysen et al. Dis. Model. Mech. 2015;8:17-30 © Published by The Company of Biologists Ltd
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