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Cellular iron: Ferroportin is the only way out

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Presentation on theme: "Cellular iron: Ferroportin is the only way out"— Presentation transcript:

1 Cellular iron: Ferroportin is the only way out
Tomas Ganz  Cell Metabolism  Volume 1, Issue 3, Pages (March 2005) DOI: /j.cmet Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Homeostatic regulation of plasma iron
Ferroportin functions as a hepcidin-regulated valve that controls the efflux of recycled, dietary, and stored iron into plasma transferrin. In turn, hepcidin levels are controlled by an as yet undefined plasma iron sensor. Oxygen and inflammatory cytokines also regulate hepcidin. Cell Metabolism 2005 1, DOI: ( /j.cmet ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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