1. Chemical Lectinology: Tools for Probing the Ligands and Dynamics of Mammalian Lectins In Vivo 
Brian Belardi, Carolyn R. Bertozzi 
Chemistry & Biology 
Volume 22, Issue 8, Pages (August 2015)
DOI: /j.chembiol
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2. Figure 1
Recent Chemical Methods Have Begun to Elucidate the Binding Partners and Dynamic Behavior of Mammalian Lectins In Vivo
(A) Metabolic labeling with crosslinking sugars can report on the in situ interactions between lectins and glycans. The black arrow indicates a covalent crosslink that has captured an endogenous lectin in vivo.
(B) Glycoprotein mimics are synthetic, multimeric structures designed to emulate the spatial distribution of glycan epitopes on natural glycoconjugate ligands.
(C) New tagging and imaging technologies for monitoring lectin trafficking and organization in vivo.
Chemistry & Biology  , DOI: ( /j.chembiol )
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3. Figure 2
Structures of Metabolic Crosslinking Sugars that Generate Nitrenes or Carbenes, Shown in Red, upon UV Exposure
These intermediates then react with lectins in vivo to form stable covalent adducts.
Chemistry & Biology  , DOI: ( /j.chembiol )
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4. Figure 3
A 3′,6-Disulfated Lewis × Glycopolymer Promotes L-Selectin Shedding from Leukocytes by Forming Membrane Clusters
Reprinted from Gordon et al. (1998b) with permission from Elsevier.
Chemistry & Biology  , DOI: ( /j.chembiol )
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5. Figure 4
The Siglec, CD22, Exists in Homomultimers on Resting B Cells but Is Unmasked in the Presence of a Multivalent Glycopolymer, BPC-NeuAc-PAA, of Sufficient Avidity
Chemistry & Biology  , DOI: ( /j.chembiol )
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6. Figure 5 A Soluble Copolymer Engages Both BCR and CD22 Simultaneously
Glycopolymer binding reorganizes CD22 to sites of BCR activation and blocks downstream signaling. The CD22 ligands are composed of sialic acid residues, suggesting that sialylation may be a molecular form of self in mammals.
Chemistry & Biology  , DOI: ( /j.chembiol )
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7. Figure 6
Fluorescent Amino Acids that Have Been Incorporated into Maltose-Binding Protein and a Sialic Acid-Binding Protein
Chemistry & Biology  , DOI: ( /j.chembiol )
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