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Proliferation at the Heart of Preadolescence

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Presentation on theme: "Proliferation at the Heart of Preadolescence"— Presentation transcript:

1 Proliferation at the Heart of Preadolescence
Nathan J. Palpant, Charles E. Murry  Cell  Volume 157, Issue 4, Pages (May 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Cardiomyocyte Proliferation and Regenerative Potential during Heart Development The transition during heart development from proliferation to terminal differentiation has just gotten more complex. In the early postnatal period (P2 mouse panel), cardiomyocytes robustly proliferate and heart muscle has the ability to fully recover from injury. This regenerative capacity is lost by postnatal day 7 and is not retained in adulthood (P21 mouse panel). Naqvi et al. now show that cardiomyocyte proliferation is reactivated during a narrow time window in the preadolescent mouse heart (P15 mouse panel), delineating the cellular and molecular processes underlying this process. These findings provide new insights into the complex relationship between proliferation and regeneration in the postnatal heart. Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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