1. Combinatorial Chemistry
Dr. Mirza Shahed Baig

13. What is it about?
Synthesising a large number of similar compounds in a short period of time.
Compounds that are generated are analogues of compounds that are already biologically active
Chemists want to find a new medicine that is more effective than an existing one, or causes fewer side effects

14. A simple model Take some beads made from a polymer
2. React the beads with a group called a linker
3. Mix the bead in with an alcohol that you want to use in a chemical reaction. The linker will bind to it and hold it on the bead.

15. A simple model
Have 6 reaction vessels each containing a different acyl chloride. Put a 1/6 of your beads into a mesh bag and put into a container.

16. A simple model Esterification occurs forming 6 different esters.
6. The beads are removed from the vessel by lifting up the mesh bag. They are washed to remove any unreacted acyl chloride

17. A simple model
7. A reaction is used to break the linker group down. 8. The polymer beads are reused 9. You have made 6 different esters which can now be tested for biological activity

18. A simple model
10. How many esters would you have made if you had attached 6 different alcohols to the beads?

19. A simple model Large numbers of similar compounds have
been synthesised in a very short period
of time. Imagine how much longer it would
take if you did the reaction with one alcohol
and acyl chloride, and then did it again with a
different acyl chloride, and then again,
and again…. 36 times!