1. Sulfated Glycoconjugates
Overview/Structure
Sulfated Glycoconjugates

2. Overview Carbohydrate linked to protein or lipid
Glycoproteins, glycolipids
External surface of the membrane

3. Sugars

4. Glycoproteins and Glycolipids
Oligosaccharide side chains contain fewer than 15 sugars
Branched and covalently linked
O- or N-linked to proteins or lipids
Cell-surface receptor molecules in cytoplasmic membrane

5. Glycoproteins and Glycolipids

6. Glycolipid Structure

7. Synthesis

8. Synthesis cont’d

9. Cell-cell adhesion Lectins recognize specific oligosaccharide chains
Sperm-egg interactions
Blood clotting
Inflammatory responses

10. Sulfated Glycoconjugates
Sulfate exists in ester linkage to oligosaccharide chains
Presence in the brain, endothelial, epithelial cells
Sulfated hormones

11. Sulfated Glycoconjugates
Strong negative charge
Molecular recognition processes
Cystic fibrosis, cancer, osteoarthritis

12. Sulfated Glycoconjugates