Download presentation
Presentation is loading. Please wait.
1
Advanced Seminars in Neuroendocrinology Fall Semester 2008
Spatial Learning Advanced Seminars in Neuroendocrinology Fall Semester 2008
2
Process Learning New Information used Adaptively modifies
Behavioral responses
3
Processed Information
Memory Processed Information used to Modify Behavioral responses
4
Memory types
5
Not Measurable Learning and Memory Directly Change over time
in Behavioral responses are measurable
6
Navigation through Space
Spatial Learning Navigation through Space Discrete Goal Cartographic Spatial Learning Navigation based on a Cognitive Map
7
Spatial Learning Positional Information Integration Changing
Environmental Perspective
8
Spatial Learning Positioning Vectors Relative to Individual
Relative to Environment Egocentric Body coordinate system Geocentric Earth coordinate system
9
Hippocampus-Necessary
Spatial Learning Hippocampus-Necessary Posterior hippocampus (humans) Dorsal hippocampus (rodents) Dorsolateral pallium (fish; DL) Left hippocampus (pigeons)
10
Spatial Learning - Hippocampus
Contextual Learning Temporal learning Relational learning All 4 incorporate environmental framework
11
Spatial Learning - Hippocampus
LTP (long term potentiation) Hebbian (pre + postsynaptic) Molecular model of learning in Hippocampal CA1-4 + DG á postsynaptic potential LTD (long term depression) â PSP Hebbian CA1-4 + DG learning model
12
Spatial Learning - Hippocampus
Ablation of hippocampus Limits spatial learning Goldfish Not acquisition Acquisition of Reversed spatial learning task
13
Spatial Learning - Hippocampus
Homing pigeons Right HF ablation Sun compass orientation
14
Spatial Learning-Stress
Prenatal Stress Reduces Hippocampal Synaptic Density Neurogenesis NO Alters Hipp Gene Expression
15
Spatial Learning-Stress
Prenatal Stress inhibits CA1 LTP + acute stress = more inhibition of CA1 LTP Facilitates CA1 LTD + acute stress enhances CA1 LTD
16
Spatial Learning-Stress
Prenatal Stress inhibits Spatial Learning Increased latency to escape to platform MWM Blah blah blah
Similar presentations
