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MicroRNAs Make a Difference in Cardiovascular Robustness

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Presentation on theme: "MicroRNAs Make a Difference in Cardiovascular Robustness"— Presentation transcript:

1 MicroRNAs Make a Difference in Cardiovascular Robustness
Rachael Bakker, Richard W. Carthew  Developmental Cell  Volume 40, Issue 6, Pages (March 2017) DOI: /j.devcel Copyright © Terms and Conditions

2 Figure 1 Bottom-Up Effect of miRNAs on Zebrafish Developmental Robustness Suppression of variation in protein expression from miRNA target genes presumably leads to a Waddington landscape in which cell fate decisions and morphogenesis are rendered robust. Waddington envisioned a developing embryonic cell like a ball rolling down a landscape, staying in valleys and seeking the lowest point (Waddington, 1942). The height of barriers (hills) correlates with the stability of developmental decisions that cells make. In the case of zebrafish, miR-24 and miR-139 increase the height of barriers, resulting in phenotypic homogeneity for cardiovascular traits. Developmental Cell  , DOI: ( /j.devcel ) Copyright © Terms and Conditions

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