2. Protein Cascades

3. Cascades
Activator
Output

4. Properties of Protein Cycles
Build a model of a protein cycle
2 Use simple irreversible mass-action kinetics for the forward and reverse arms.
3. Investigate how the steady state concentration of the phosphorylated protein changes as a function of the forward rate constant.

5. Cascades

6. Properties of Protein Cycles
1. Investigate what happens when you use simple irreversible Michaelis-Menten Kinetics.
2. Investigate how the response changes as you decrease the two Kms

7. Ultrasensitivity

8. Multiple Protein Cycles forming a Cascade
Activator
Cascade two cycles together

9. Exercise
Activator
Output

10. Cascades

11. Cascades
1. Investigate what happens when you use simple irreversible Michaelis-Menten Kinetics.
2. Investigate how the response changes with the two Kms