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Volume 57, Issue 2, Pages (October 2000)

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Presentation on theme: "Volume 57, Issue 2, Pages (October 2000)"— Presentation transcript:

1 Volume 57, Issue 2, Pages 526-533 (October 2000)
Contribution of γ glutamyl transpeptidase to oxidative damage of ischemic rat kidney  Juan C. Cutrín, M.D., Ph.D., Barbara Zingaro, Simonetta Camandola, Alberto Boveris, Alfonso Pompella, Giuseppe Poli  Kidney International  Volume 57, Issue 2, Pages (October 2000) DOI: /j x Copyright © 2000 International Society of Nephrology Terms and Conditions

2 Figure 1 Effects of 25 minutes of ischemia on the γ glutamyl transpeptidase (GGT) activity of rat kidney. (A) Cortex. (B) Outer medulla. Values are means ± SE from five rats per experimental group. aDifferent from control (P < 0.05); bdifferent from ischemia (P < 0.01); cdifferent from control (P < 0.05). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

3 Figure 2 Histochemistry of GGT activity in kidneys from control and acivicin-pretreated rats. (a) Renal inner cortex of a control rat. (b) Renal inner cortex of a rat pretreated with acivicin. G, glomeruli; arrows, proximal tubules. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

4 Figure 3 Histochemistry of GGT activity in the inner cortex of ischemic rat kidneys in the presence or absence of acivicin pretreatment. (a) Inner cortex of ischemic kidney from acivicin-untreated animal. (b) Inner cortex of ischemic kidney from acivicin-treated rat. Arrows, proximal tubules; arrowheads, desquamated tubular cells; asterisks, dilated proximal tubules. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

5 Figure 4 Histochemistry of GGT activity in the outer medulla of ischemic rat kidneys in the presence or absence of acivicin treatment. (a) Outer medulla of ischemic kidney from control rat. (b) Outer medulla of ischemic kidney from acivicin-treated rat. Arrows, proximal tubules; arrowheads, desquamated tubular cells; asterisks, dilated proximal tubules. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

6 Figure 5 Effect of 25 minutes of ischemia on malondialdehyde (MDA) levels in rat kidney. (A) Cortex. (B) Medulla. Values are means ± SE from five animals per experimental group. aDifferent from control (P < 0.05); bdifferent from ischemia + acivicin (P < 0.001). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

7 Figure 6 Effect of 25 minutes of ischemia on GSH content of rat kidney. (A) Cortex. (B) Medulla. Values are means ± SE from five animals per experimental group. aDifferent from control (P < 0.001); bdifferent from control (P < 0.01); cdifferent from ischemia (P < 0.03). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions


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