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A Modified Haploidentical Nonmyeloablative Transplantation without T Cell Depletion for High-Risk Acute Leukemia: Successful Engraftment and Mild GVHD 

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Presentation on theme: "A Modified Haploidentical Nonmyeloablative Transplantation without T Cell Depletion for High-Risk Acute Leukemia: Successful Engraftment and Mild GVHD "— Presentation transcript:

1 A Modified Haploidentical Nonmyeloablative Transplantation without T Cell Depletion for High-Risk Acute Leukemia: Successful Engraftment and Mild GVHD  Mei Guo, Zhao Sun, Qi-Yun Sun, Qin Han, Chang-Lin Yu, Dan-Hong Wang, Jian-Hui Qiao, Bin Chen, Wan-Jun Sun, Kai-Xun Hu, Guang-Xian Liu, Bing Liu, Robert Chunhua Zhao, Huisheng Ai  Biology of Blood and Marrow Transplantation  Volume 15, Issue 8, Pages (August 2009) DOI: /j.bbmt Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Sketch of nonmyeloablative conditioning Conditioning consisted of fludarabine 30 mg/m2/d (days -6 to -2), total body irradiation (60Co) 2Gy (day -1), cyclophosphamide (CTX) 40 mg/kg/d (days -4, -2), Ara-C (cytarabine) 1.5∼2.0 g/m2(days -6 to -3), and rabbit anti-human thymocyte globulin (ATG, France) 1.5∼2.0 mg/kg/d (days -4 to -1). Abbreviations: CSA, cyclosporin A; MMF, mycophenolate mofetil; CD25Ab, anti CD25 antibody. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Probability of leukemia-free survival after transplantation. The follow-up months, 20 (60.6%) of thirty-three patients were still alive well. As shown in Figure 2, The probability of 3 year leukemia-free survival in AML patients was 68.0%, which was significantly higher than that ALL patients (45.0%, P=0.014). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions


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