1. Temporal order of mutational processes during cancer evolution.
Temporal order of mutational processes during cancer evolution. A, a schematic of mutations accumulating during cancer. Mutations can be temporally dissected from sequencing data by determining which mutations occurred before or after genome doubling or amplification events and also identifying mutations occurring before or after subclonal diversification. GD, genome doubling. B, a diagram of the evolutionary history of a lung adenocarcinoma. The APOBEC signature appears to occur prior to subclonal diversification but after genome doubling. A mutation in PIK3CA occurs in an APOBEC context. Figure is adapted from ref. 59.
Charles Swanton et al. Cancer Discovery 2015;5:
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