1. Visualization of lineage radius increase.
Visualization of lineage radius increase. A lineage from participant YN1 at day 0 and day 28 is shown as a phylogenetic tree based on the edit distance between CDR3 sequences. Each leaf corresponds to one sequence, colored according to the time point at which it was observed. The axis measures distance (branch length) as the number of nucleotide substitutions. In this example, the “lineage radius increase from day 0 to day 28” (largest distance between any two gray or black sequences on the tree MINUS largest distance between any two black sequences) is 2. For each time point, the branches joining two sequences with the maximum edit distance between them are highlighted in bold.
Charles F. A. de Bourcy et al. PNAS 2017;114:5:
©2017 by National Academy of Sciences