1. Activity flow of PDGFR signaling pathways.
Activity flow of PDGFR signaling pathways. Activity flow diagram of broad PDGFR signaling. Components and reactions that are central to PDGFR signaling were extracted from the more comprehensive maps (Figs 2 and S1) to produce a reduced complexity map highlighting the flow of activation and inhibition of signaling members. The resulting downstream activities of the core components have significant roles in controlling diverse biological responses. Arrows in the diagram represent the flow of reaction with positive (red) and negative feedback (blue) loops represented by bold lines. Direct downstream molecules uniquely regulated by PDGFRα and PDGFRβ receptors are indicated in blue and orange, respectively. Symbols are identical to those used in Figs 2 and S1 legends. The high-resolution PDF is available in the Supplementary Information.
Shuang Zhou et al. LSA 2018;1:e
© 2018 zhou et al.