1. Personalized Medicine
What is
Personalized Medicine ?

2. Personalized Medicine
“One size fits all” model
Personalized medicine
An extension of traditional medicine
A focus on genetic map and proteomics
“Personal” treatment

3. Personalized Medicine
Go with Tumor
Chen Wanna
Ma Linxiaoxi

4. SHIVA trial

5. Applications Disease-causing mutation test --to prevent cancers
Cancer prevention

6. Applications Targeted therapy HER2 (Chromosome17q12-21.32)
Trastuzumab/Herceptin
Choosing effective drugs
Reducing the dose and waste of medicine
Avoiding undesirable side effects

7. Applications Minimal residual disease tests(MRD)
--to quantify residual cancer
Medication or surgery on tumor
Detecting the special protein markers on the tumor cells
Finding the existence of tumor cells not cleaned absolutely

8. Problems Genetic discrimination Rising cost of treatment
Medication safety

9. References http://en.wikipedia.org/wiki/Personalized_medicine
Hong K W, Oh B. Overview of personalized medicine in the disease
genomic era[J]. BMB Rep, 2010,43(10):
Garcia I, Kuska R, Somerman M J. Expanding the Foundation for
Personalized Medicine: Implications and Challenges for Dentistry[J].
J Dent Res, 2013.
Le Tourneau C, Kamal M, Trédan O, etal. Designs and challenges 
for personalized medicine studies in oncology: focus on the SHIVA
trial[J]. Target Oncol. 2012, 7(4):
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10. Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions we know as disease.
--Sir William Osler ( )