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Jie Hu, Malini Sathanoori, Sally J. Kochmar, Urvashi Surti 

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Presentation on theme: "Jie Hu, Malini Sathanoori, Sally J. Kochmar, Urvashi Surti "— Presentation transcript:

1 Application of Multicolor Banding for Identification of Complex Chromosome 18 Rearrangements 
Jie Hu, Malini Sathanoori, Sally J. Kochmar, Urvashi Surti  The Journal of Molecular Diagnostics  Volume 8, Issue 4, Pages (September 2006) DOI: /jmoldx Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Partial High-resolution G-banded karyotypes of the cell lines showing ring chromosome 18 (left) and derivative chromosome 18 (right). The Journal of Molecular Diagnostics 2006 8, DOI: ( /jmoldx ) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 A: FISH with the l8ptel probe showing two signals on each arm of the derivative chromosome. B: The derivative chromosome 18 negative for the 18qtel probe. The Journal of Molecular Diagnostics 2006 8, DOI: ( /jmoldx ) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4 Figure 3 mBAND image and profiles showing the normal 18 (top) and the derivative chromosome 18 with deletion and duplication (bottom). The Journal of Molecular Diagnostics 2006 8, DOI: ( /jmoldx ) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

5 Figure 4 mBAND image and profiles showing the normal 18 (top) and the ring chromosome 18 (bottom). The Journal of Molecular Diagnostics 2006 8, DOI: ( /jmoldx ) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

6 Figure 5 A and B: Schematic representation of two suggested mechanisms for origin of the two derivative cell lines. The Journal of Molecular Diagnostics 2006 8, DOI: ( /jmoldx ) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

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