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Mechanisms of chronic tophaceous gout.

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Presentation on theme: "Mechanisms of chronic tophaceous gout."— Presentation transcript:

1 Mechanisms of chronic tophaceous gout.
Mechanisms of chronic tophaceous gout. Neutrophil granulocytes ingest needle-shaped MSU crystals (yellow). During low concentrations of neutrophils, this process releases cytokines (red dots) and recruits further cells. On ingestion of MSU crystals, neutrophils undergo a specific form of cell death known as NETosis. NET resembles extracellular DNA. The extrusion of DNA during NETosis densely packs MSU crystals and cytokines. The high number of neutrophils at sites of MSU deposits allows the formation of aggregated NETs, which are highly effective in degrading cytokines (IL-1, interleukin 1; MSU, monosodium urate; NET, neutrophil extracellular trap). Georg Schett et al. RMD Open 2015;1:e000046 Copyright © BMJ Publishing Group & EULAR. All rights reserved.

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