1. Crystal Structures of Human GlyRα3 Bound to Ivermectin
Xin Huang, Hao Chen, Paul L. Shaffer 
Structure 
Volume 25, Issue 6, Pages e2 (June 2017)
DOI: /j.str
Copyright © 2017 Elsevier Ltd Terms and Conditions

2. Structure 2017 25, 945-950.e2DOI: (10.1016/j.str.2017.04.007)
Copyright © 2017 Elsevier Ltd Terms and Conditions

3. Figure 1
Crystal Structure of GlyRα3 in Complex with AM-3607, Glycine, and Ivermectin
(A) Viewed parallel to the plasma membrane. Each subunit is colored separately. AM-3607, glycine, and ivermectin are shown as green sticks. Zn2+ is shown as a gray sphere and Cl− is shown as a green sphere.
(B) Viewed from the extracellular side down the pore axis.
(C) Viewed from the intracellular side down the pore axis.
Structure  , e2DOI: ( /j.str )
Copyright © 2017 Elsevier Ltd Terms and Conditions

4. Figure 2 Ivermectin Binding to GlyRα3
(A) Viewed parallel to the membrane. The principal(+) subunit is colored cyan and the complementary(−) subunit is colored purple. Ivermectin is shown as green sticks. The dashed lines indicate hydrogen bonds.
(B) Viewed down the pore from extracellular side with the ECD removed for clarity.
(C) Superposition of ivermectin (green)-bound GlyRα3 (cyan and purple), and ivermectin (yellow)-bound GluCl (teal and pink) viewed parallel to the membrane.
(D) Chemical structure of ivermectin with hydrogen bond and hydrophobic interactions indicated. Solvent exposure is showed as shading. The principal(+) subunit is labeled (A) and complementary(−) subunit is labeled (B).
Structure  , e2DOI: ( /j.str )
Copyright © 2017 Elsevier Ltd Terms and Conditions

5. Figure 3
| The Ion Channel of the GlyRα3/AM-3607/Glycine/Ivermectin Complex in a Desensitized State
(A) Solvent contours of the transmembrane pore of the ivermectin-bound GlyRα3 pore showing the M2 helices of subunits (A) and (C). Side chains of pore lining residues are shown. Numbering is according to the protein sequence and position in the M2 helix. Small purple, green, and red spheres define a radius of >3.3, 1.8–3.3, and <1.8 Å, respectively.
(B) Contours of the glycine-bound GlyRα1 pore (PDB: 3JAE), similar to (A).
(C) Plot of pore radii as a function of distance along the pore axis for glycine/AM-3607/ivermectin-bound GlyRα3, strychnine-bound GlyRα3 (PDB: 5CFB), glycine-bound GlyRα1 (PDB: 3JAE), glycine/ivermectin-bound GlyRα1 (PDB: 3JAF), ivermectin-bound GluCl (PDB: 3RHW), and benzamidine-bound GABAARβ3 (PDB: 4COF).
Structure  , e2DOI: ( /j.str )
Copyright © 2017 Elsevier Ltd Terms and Conditions

6. Figure 4
Key Interactions between the Subunits of TMD Viewed Down the Pore from Extracellular Side with the ECD Removed for Clarity
(A) The AM-3607 and glycine-bound state. Dashed lines indicate hydrogen bonds and salt bridges.
(B) The ivermectin-bound state. Ivermectin is shown as green sticks.
Structure  , e2DOI: ( /j.str )
Copyright © 2017 Elsevier Ltd Terms and Conditions