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Status of Donor-Recipient HLA Class I Ligands and Not the KIR Genotype Is Predictive for the Outcome of Unrelated Hematopoietic Stem Cell Transplantation.

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Presentation on theme: "Status of Donor-Recipient HLA Class I Ligands and Not the KIR Genotype Is Predictive for the Outcome of Unrelated Hematopoietic Stem Cell Transplantation."— Presentation transcript:

1 Status of Donor-Recipient HLA Class I Ligands and Not the KIR Genotype Is Predictive for the Outcome of Unrelated Hematopoietic Stem Cell Transplantation in Beta- Thalassemia Patients  Giorgio La Nasa, Roberto Littera, Franco Locatelli, Claudio Giardini, Arianna Ventrella, Marina Mulargia, Adriana Vacca, Nicola Orrù, Sandro Orrù, Eugenia Piras, Giada Giustolisi, Daniela Lisini, Sonia Nesci, Giovanni Caocci, Carlo Carcassi  Biology of Blood and Marrow Transplantation  Volume 13, Issue 11, Pages (November 2007) DOI: /j.bbmt Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Kaplan-Meier probabilities of overall survival, thalassemia-free survival and cumulative incidence of mortality and rejection in 45 thalassemia patients transplanted from an unrelated donor. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Influence of heterozygosity for the HLA-Cw ligand groups 1 and 2 (C1/C2) on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (C1/C2 patients = 22, events = 10; C1/C1 patients = 9, events = 0; C2/C2 patients = 14, events = 2). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Influence of homozygosity for the HLA-Cw ligand groups (C1/C1 or C2/C2) on the cumulative incidence of rejection in 45 thalassemia patients transplanted from an unrelated donor. (C1/C1 patients = 9, events = 3; C2/C2 patients = 14, events = 4; C1/C2 patients = 22, events = 0). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Comparison of the probabilities of thalassemia-free survival (TFS) between 22 C1/C2 heterozygotes (events = 18) and 23 C1/C1 or C2/C2 homozygotes (C1/C1 patients = 9, events 6; C2/C2 patients = 14, events = 8). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 Impact of the presence of the HLA-A11 KIR antigen on the incidence of grade II-IV aGVHD in 45 thalassemia patients transplanted from an unrelated donor. (HLA-A11 positive patients = 11, events = 0; HLA-A11 negative patients = 34, events 12). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions


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