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B. Mohanraj, M. Kim, F. Tu, D. Lee, R.L. Mauck, G.R. Dodge 

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Presentation on theme: "B. Mohanraj, M. Kim, F. Tu, D. Lee, R.L. Mauck, G.R. Dodge "— Presentation transcript:

1 Loading induced ‘on-demand’ delivery from mechanically activated microcapsules 
B. Mohanraj, M. Kim, F. Tu, D. Lee, R.L. Mauck, G.R. Dodge  Osteoarthritis and Cartilage  Volume 24, Pages S166-S167 (April 2016) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1. (A-B) Schematic of double emulsion microcapsule generation (C-E) Fabrication parameters determine MAMC dimensions (F-G) MAMCs containing dextan (green with labeled shells (red) deform and fracture under load dependent on the vD ratio (slopes differ: **p<0.01) Osteoarthritis and Cartilage  , S166-S167DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2. (A-B) Degradation time influences PLGA MAMC mechano-activation profile (C) Volume reconstructions and SEM of control vs. ruptured MAMCs Osteoarthritis and Cartilage  , S166-S167DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Figure 3. (A-B) MAMC deformation (aspect ratio
Figure 3. (A-B) MAMC deformation (aspect ratio. AR) with hydropel deformation: MAMCs ruptured only upon hydrogel fracture (n=11 MAMCs from three separate hydrogels). Osteoarthritis and Cartilage  , S166-S167DOI: ( /j.joca ) Copyright © Terms and Conditions


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