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Diminished intrafollicular estradiol levels in in vitro fertilization cycles from women with reduced ovarian response to recombinant human follicle-stimulating.

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Presentation on theme: "Diminished intrafollicular estradiol levels in in vitro fertilization cycles from women with reduced ovarian response to recombinant human follicle-stimulating."— Presentation transcript:

1 Diminished intrafollicular estradiol levels in in vitro fertilization cycles from women with reduced ovarian response to recombinant human follicle-stimulating hormone  Shu C. Foong, M.D., David H. Abbott, Ph.D., Timothy G. Lesnick, M.S., Donna R. Session, M.D., David L. Walker, M.S., Daniel A. Dumesic, M.D.  Fertility and Sterility  Volume 83, Issue 5, Pages (May 2005) DOI: /j.fertnstert Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Correlation between the amount of recombinant hFSH (rhFSH) administered and intrafollicular level of immunoreactive FSH (iFSH) in nonhirsute ovulatory women receiving GnRH agonist and recombinant hFSH therapy for IVF (R2 = 0.3, P<.0001). FF = follicular fluid. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Intrafollicular E2 levels in cycles of high-normal and low-normal response in nonhirsute ovulatory women receiving GnRH agonist and recombinant hFSH therapy for IVF. Open and filled circles represent data from both sides per patient. Box plots extend from 25th to 75th percentiles, with a horizontal line at the median. Whiskers extend to the outermost data point that falls within the distance computed as (upper quartile × [interquartile range]) and (lower quartile − 1.5 × [interquartile range]). The difference shown is statistically significant (P<.01). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions


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