1. Bispecific Antibodies Against HIV
David C. Montefiori 
Cell 
Volume 165, Issue 7, Pages (June 2016)
DOI: /j.cell
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1 Two Classes of Synergistic Bispecific Antibodies
In the class described by Huang et al. (2016) (A), one arm of IgG binds an epitope in the membrane proximal external region (MPER) of gp41. The other arm binds either the HIV-1 receptor molecule, CD4, or coreceptor molecule, CCR5, on the surface of susceptible cells, in this case a helper T cell. The class described by Bournazos et al. (2016) (B) exhibits bivalent, intra-trimeric binding to the envelope glycoprotein spike via an epitope in the CD4 binding site of one gp120 monomer and a second epitope at the C-terminal base of the V3 loop of an adjacent gp120 monomer. Both classes of bispecific antibodies exhibit broad and potent synergistic neutralization of HIV in vitro.
Cell  , DOI: ( /j.cell )
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