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ESCRTing Necroptosis Cell

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Presentation on theme: "ESCRTing Necroptosis Cell"— Presentation transcript:

1 ESCRTing Necroptosis Cell
Hongyan Guo, William J. Kaiser  Cell  Volume 169, Issue 2, Pages (April 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 ESCRT-III Antagonizes Necroptosis
Necroptosis induction after TNF stimulation or drug-inducible oligomerization of RIPK3 or MLKL leads to rapid Ca2+ influx and phosphotidylserine (PS) exposure prior to membrane permeabilization. ESCRT-III components are recruited to localized sites of MLKL-directed membrane damage and resuscitate necroptotic cells by actively shedding broken membrane blebs. Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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