1. Where is the lesion ?

2. Anisometropic
Stimulus Deprivation
Strabismic

3. Stimulus Deprivation
Lid closure in cats or monkey, fine-detail cells (X cells) in the geniculate are larger than normal, and movement cells (Y cells) are smaller than normal (Sur M; 1982)

5. Stimulus Deprivation
Projections from lateral geniculate nucleus to visual cortex are similarly affected. Cortical stripes from the affected eyes are narrower than normal (Hubel DH; 1975)

6. Anisometropic
In primates given atropine, cells in visual cortex reduced contrast sensitivity; most prominent in striae cortex layer IV and IV (Movshon JA; 1987)

7. Strabismic
Reduction of cells in the visual cortex (Kiorper L; 1981)

8. Strabismic amblyopic eye has thinner nerve fiber layer (Colen TP; 2000)
Controversial (Baddini-Caramelli C; 2000)

9. Neurotransmitters ??
Anoxia increased central scotoma while oxygen had a beneficial effect ( Biette; 1950)
GABA-receptor blocker (Bicuculline) in reversing visual deprivation (Duffy; 1955)
Nerve growth factor prevented the shrinkage of cells in LGN(Maffei; 1993)

10. Role of levodopa and citicoline