1. Chapter 3 - The Immune System

2. What are germs?
We all have heard that washing your hands helps stop the spread of germs…
What are “germs” exactly?
Germs are disease-causing invaders or organisms, also called pathogens.
These pathogens enter the body and can cause disease if not attacked by the immune system.

3. Some pathogens being analyzed under a microscope

4. Bacterial and viral pathogens

5. Water-bourne pathogens can pose serious health-risks for people.
Outbreaks caused by bacteria (samonella, E-coli) and viruses (Hepatitis A) in drinking water have happened in Canada.

6. An Elm tree with Dutch Elm’s
Disease.
The tree will eventually die.

7. Infectious Diseases
Infectious disease can be transmitted in a variety of ways.
In each case, the pathogen (disease causing organism) finds away to get into the body.
What are some ways?
Direct contact (shaking hands)
Indirect contact (sneezing)
Through water and food that is infected
Animal bites (ex: rabies virus)

9. Did You Know?
Way back in the day, surgeons didn’t use sterilized operating tools and they didn’t usually wash their hands before operating!
As a result, most people died after having surgery (due to infectious disease).

10. So Why Aren’t We Sick All the Time?
Because we have a built-in system to help fight pathogens
Immune System
The immune system has 2 lines of defense
1 –Skin and lining of internal organs
2 – Immune response (attacks invader)

11. First Line Of Defense - Skin
Why do we have skin???
For protection
Your skin acts as a barrier to keep pathogens OUT of the body.
Our skin also contains sweat and oils that help prevent pathogen growth because they are slightly acidic.

13. First Line Of Defense - Skin
Lining inside the body also helps protect us against pathogens!
Stomach lining
Secretes gastric juice (acidic!) that destroys pathogens that enter the stomach
Nose lining
Cilia and mucus prevent pathogens from entering the respiratory system

14. Second Line Of Defense
If pathogens get by the first line of defense… the body must DESTROY the invader!
Your body launches an immune response.
If your body recognizes a cell as an invader (not one of your own cells), it attacks it.
2 Types:
(1) Innate immune response
(2) Acquired immune response

15. 2 Types of Immune Response
1. Innate immune response
All living things can mount this type of response
We are born with it (innate)
It is quick and non-specific
The body attacks anything that it recognizes as an invader
How does it work???

16. 2 Types of Immune Response
1. Innate immune response
A flow of fluid, cells and dissolved substances from the blood go to the site of infection.
This causes a fever
This also causes swelling and redness in the area (known as inflammation)
There is an increase of white blood cells (called phagocytes)

17. Phagocytes (cell-eaters!)
What are they?
Type of white blood cell
Recall: white blood cells fight infection
They roam around the body looking for invaders and when they find them….
They swallow them!

18. 2 Types of Immune Response
1. Acquired immune response
Very specific immune response
An attack is launched on a specific invader
Pathogen or antigen
What is an antigen?
A non-living particle that your body recognizes as an invader (ex: virus, sliver…)

19. Acquired Immune Response
There are 2 ways your body can mount an acquired immune response.
Both ways involve white blood cells called
B cells and T cells
Acquired immune response takes longer than innate response (up to a week).

20. Acquired Immune Response
#1 – Antigen in body (B cells in action)
B cells recognize specific antigens
Produce antibodies to fight the antigens
Antibodies ATTACH to antigen or pathogen
Antibodies either
Mark the antigen/ pathogen to be destroyed or
prevent it from entering body cell

21. Antibodies attaching to antigen

22. Acquired Immune Response
#1 – Antigen inside body cell (T cells in action)
White blood cell recognize antigen/ pathogen
Signals for T cells to be produced
Helper T cells recognize presence of antigen/ pathogen and activates B cells
B cells produce antibodies
Antibodies destroy antigen/ pathogen

23. T cells Helper T cells signal the B cells to START.
We also have T cells that tell the B cells to STOP producing antibodies.

24. T cells There is another type of T cell (other than helper T cells)
A second type is called killer T cells
These T cells can directly destroy antigens or pathogens
Killer T cells kill a cancer cell

25. Acquired Immune Response
What is immunity?
(not just something on Survivor!)…
After an attack, some antibodies remain in the body.
These antibodies protect against future infection of the same antigen/ pathogen
This protection is called immunity!

26. Immunity
When your body remembers which antibodies to use for a pathogen it has encountered before…
This is called “active immunity”
The B cells that remember and produce the antibodies are called
memory B cells

27. Acquired Immune Response
Let’s sum it up…
4 Main Steps:
Recognition
Mobilization
(B cells make antibodies)
3) Disposal
(antibodies destroy invader)
4) Immunity
(left over antibodies for future)