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Statistical Treatment of Fluorescence in Situ Hybridization Validation Data to Generate Normal Reference Ranges Using Excel Functions  Allison L. Ciolino,

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Presentation on theme: "Statistical Treatment of Fluorescence in Situ Hybridization Validation Data to Generate Normal Reference Ranges Using Excel Functions  Allison L. Ciolino,"— Presentation transcript:

1 Statistical Treatment of Fluorescence in Situ Hybridization Validation Data to Generate Normal Reference Ranges Using Excel Functions  Allison L. Ciolino, Mary E. Tang, Ron Bryant  The Journal of Molecular Diagnostics  Volume 11, Issue 4, Pages (July 2009) DOI: /jmoldx Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Binomial distribution functions with 95% confidence limits indicated. A: p = 0.013, n = 100, k0.95 = 3; B: p = 0.013, n = 500, k0.95 = 11. The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 Normal cut-off values at the 95% confidence limit calculated from the simulated validation data in Table 2 calculated by three methods. Binomial: ‘o’; Gaussian (DeMoivre-Laplace): ‘*’; and β inverse: ‘x’. The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

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