1. Something we learn from textbook
White fat cell
Store energy
Monolocular(单房的)
Brown fat cell
Dissipate energy
[high mitochondrial UCP1(uncoupling protein 1)]
Multilocular
In small mammals, not in large mammals after infancy
UCP1,tanslocating proton across mitochondrial membrane as to uncouple oxidation and phosphorylation, classically associated with the nonshivering thermogenesis of brown adipose tissue(BAT).

2. Some new progress “brown conversion”of white fat
Brown fat in adult humans
UCP1+
Particularly in supraclavicular and neck region
cold or cAMP
White fat tissue
UCP1﹣
UCP1+
brown fat cell
UCP1+
Derived from myf-5 lineage

3. Questions
Beige fat cell is a distinct cell type or derived from white fat cells ？
The brown fat tissue in adult human is classical brown fat or beige fat ?

4. 第一PPT模板网 Lecturer: Cao Lijie WAT: white adipose tissue
BAT: brown adipose tissue
Lecturer: Cao Lijie

5. Beige adipocyte in white fat
Beige fat cell readily detectable in Inguinal subcutaneous fat depot
Multilocular
UCP1 between WAT and BAT
BAT
Inguinal subcutaneous fat depot
Epididymal WAT
Brown fat cell-enriched protein

6. Beige adipocyte in white fat
Ing
Immortalization(无限增殖) … …
cell lines
differentiate … …
Inguinal subcutaneous fat depot
Immortalizing(无限增殖) into 23 cell lines
Gene expression analysis
Two distinct adipose cell type, one of them is more similar to brown fat cell.
A subset of clones precursor cells within white fat give rise to beige adipocyte
beige fat cell
White fat cell
Beige fat cell is derived from a subset of
precursor cells within white fat.

7. characteristics of Beige cells
(By cAMP)
reaching similar absolute level to that of BAT
Brown fat-- enriched protein

8. Brown fat in adult humans are beige fat cells

9. highlights “Brown” fat in human adults is composed of beige adipocytes
subQ WAT
Beige adipogenic cells
White adipogenic cells
Sympathetic stimulation
Beige adipocyte
“Brown” fat in human adults is composed of beige adipocytes