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Volume 9, Issue 1, Pages (January 2012)

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1 Volume 9, Issue 1, Pages 77-83 (January 2012)
Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome  Hiro Kawata, MD, Takashi Noda, MD, PhD, Yuko Yamada, MD, Hideo Okamura, MD, Kazuhiro Satomi, MD, PhD, Takeshi Aiba, MD, PhD, Hiroshi Takaki, MD, Naohiko Aihara, MD, Mitsuaki Isobe, MD, PhD, Shiro Kamakura, MD, PhD, Wataru Shimizu, MD, PhD  Heart Rhythm  Volume 9, Issue 1, Pages (January 2012) DOI: /j.hrthm Copyright © 2012 Heart Rhythm Society Terms and Conditions

2 Figure 1 A: Twelve-lead ECG in a patient with early repolarization syndrome. ER (arrow) was seen in the lateral leads (V4–V6) under baseline conditions. B: Monitor ECG recorded during the arrhythmic periods in the same patient showed a consistent increase in the amplitude of ER, followed by initiation of ventricular fibrillation. ECG, electrocardiogram; ER, early repolarization. Heart Rhythm 2012 9, 77-83DOI: ( /j.hrthm ) Copyright © 2012 Heart Rhythm Society Terms and Conditions

3 Figure 2 Twelve-lead ECGs in a patient with early repolarization syndrome under baseline conditions (A) and after pilsicainide administration (B). ER was seen in the lateral leads (I, aVL, and V4–V5) under baseline conditions (A, arrows). Intravenous administration of 30 mg of pilsicainide induced attenuation of ER and appearance of an S wave in the lateral leads (dashed arrows). Numbers above the arrows indicate the amplitude of ER. ECG, electrocardiogram; ER, early repolarization; S, S wave. Heart Rhythm 2012 9, 77-83DOI: ( /j.hrthm ) Copyright © 2012 Heart Rhythm Society Terms and Conditions

4 Figure 3 Twelve-lead ECGs in a patient with Brugada syndrome under baseline conditions (A) and after pilsicainide administration (B). ER was seen in the inferior (II, III, and aVF) and lateral (V4–V6) leads under baseline conditions (A, arrows). Intravenous administration of 30 mg of pilsicainide unmasked coved-type Brugada ECG and remarkably augmented the J point and ST segment in the right precordial leads (V1–V3) (B, dashed arrows), while ER was attenuated in the inferior and lateral leads (B, arrows). Numbers above the arrows indicate the amplitude of ER. ECG, electrocardiogram; ER, early repolarization. Heart Rhythm 2012 9, 77-83DOI: ( /j.hrthm ) Copyright © 2012 Heart Rhythm Society Terms and Conditions


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