1. The site to download BALBES:
A Molecular Replacement Pipeline Fei Long Chemistry Department, University of York
The site to download BALBES:

2. According to the data released on Protein Data Bank (PDB) In 2006
Total number of protein structures solved by X-ray crystallography :
The number solved by molecular replacement (MR) : (67.5%)
In 2007
Total number of protein structures released :
Total number solved by X-ray crystallography : (85.4%)
The number solved by MR : (67.3% of X-ray) .

3. Diagram showing the percentage of structures in the PDB solved by different techniques of macromolecular crystallography in 2007
(in 10.5% of PDB entries the technique used for structure determination is not specified clearly)

4. Recent Developments in BALBES:
Currently, two versions of BALBES are developed in in parallel. Version A is the current released version in which the internal database is continually updated and some functions are added. Version B involves large re-organization, and is currently under test.
Version A ( the current released version)
The internal database has been updated every half month. It now contains about 16,000 non-redundant entries (out of about 50,000 PDB files) and 23, 000 domain definitions.

5. Version A ( the released version)
The tests on newly obtained data are kept on every half month and successful rates is between 75% and 85% (biased) each time.
It is implemented on the YSBL server. People start to use it. 140 registered users have been tried 667 time since July 2007.
It can use the user’s own database
It can use the model PDB file from a user
BALBES can be used to provide search models only

6. Version A ( the released version)
Full test of space groups is implemented in BALBES. If a user requests to do it, BALBES will start to find out all possible candidates of space groups according to that in the input data (e.g. mtz) file, and then generate a set of new mtz files. Then if you run BALBES on a cluster, it will execute a set of jobs simultaneously and suggest the best solution. If you run BALBES on an individual computer, it will run all those mtz files in turn and again suggest the best one.

7. Developments in BALBES:
2. Version B (based on Alexei’s blueprint)

8. 2. Version B (larger structural reorganization)
The complex models are more properly handled
New algorithms to combine the different models with or without use of input phase
New algorithms to handle multiple domains
New Quality factors to make decisions (testing).

9. 2. Version B (larger structural reorganization)
The version is currently under test (except the part using experimental phase). Test result has showed slight better performance than the version A.
The problem is the presentation of the process and the results, which currently is confusing and two complex.

10. The Future Developments:
Improve the presentation of version B and release it
Sad phasing
Twins
(Not related to BALBES) I have restarted development of a Global Optimization program, it will be tested in the next a few weeks on JLigand.
BALBES is being used through downloading and the web server. Several PDB files, such as 2QQ2, 2Q87, have named BALBES as their structure determination software