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K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

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Presentation on theme: "K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F"— Presentation transcript:

1 The effect of RhoA/ROCK signaling inhibition on the development of hMSC-based chondrogenic tissue 
K.-C. Wang, E. Kwan, K. Aris, T.T. Egelhoff, A.I. Caplan, J.F. Welter, H. Baskaran  Osteoarthritis and Cartilage  Volume 25, Pages S77-S78 (April 2017) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1 hMSC aggregates of control (left), Y27632 treatment for day 0–14 (middle) and day 0–21 (right) harvested after 21-day culture (top row) and stained with Safranin O (bottom row). Scale bars: 1 mm. Osteoarthritis and Cartilage  , S77-S78DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2 RhOA/ROCK inhibition increased GAG (2A Left) and collagen (2A Right) content in aggregates. The inhibition also increased glucose consumption rate (red line, 2B Left) and the amount of fluorescent tracer (10 kDa) transported into the aggregate over one hour (2B Right) (Number of aggregates ≥ 6 for all experiments). Osteoarthritis and Cartilage  , S77-S78DOI: ( /j.joca ) Copyright © Terms and Conditions


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