1. A Powerful Pathway-Based Adaptive Test for Genetic Association with Common or Rare Variants 
Wei Pan, Il-Youp Kwak, Peng Wei 
The American Journal of Human Genetics 
Volume 97, Issue 1, Pages (July 2015)
DOI: /j.ajhg
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

2. Figure 1
Empirical Power for Simulation Set-up B with a Pathway of 20 Genes
One gene included one causal SNP.
(A and C) Each gene contained 1–20 independent (A) or correlated (C) SNPs.
(B) Each gene contained 3–100 independent SNPs.
(D) Each gene contained 1–20 correlated SNPs and the causal SNP was excluded in analysis.
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

3. Figure 2
Empirical Power for Simulation Set-up C with a Pathway of 20 Genes
Five genes each included one causal SNP.
(A and C) Each gene contained 1–20 independent (A) or correlated (C) SNPs.
(B) Each gene contained 3–100 independent SNPs.
(D) Each gene contained 1–20 correlated SNPs and the causal SNP was excluded in analysis.
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

4. Figure 3
Empirical Power for Simulation Set-up D with a Pathway of 20 Genes
Ten genes each included one to three causal SNPs.
(A and C) Each gene contained 1–20 independent (A) or correlated (C) SNPs.
(B) Each gene contained 3–100 independent SNPs.
(D) Each gene contained 1–20 correlated SNPs and the causal SNP was excluded in analysis.
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

5. Figure 4
Empirical Power for Simulation Set-up D′ with a Pathway Containing 20 Genes
Ten genes each included one to three causal SNPs.
(A and C) Each gene contained 1–20 independent (A) or correlated (C) SNPs.
(B) Each gene contained 3–100 independent SNPs.
(D) Each gene contained 1–20 correlated SNPs and the causal SNP was excluded in analysis.
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

6. Figure 5
Empirical Power for Simulation Set-ups E and F with a Pathway Containing 40 and 80 Genes, Respectively
Ten genes each included 1–3 causal SNPs, and each gene contained 1–20 correlated SNPs. Set-up E with a pathway of 40 genes (A) and set-up F with a pathway of 80 genes (B) are shown.
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

7. Figure 6
Empirical Power for RVs in Simulation Set-up D2 with a Pathway Containing 20 Genes
Ten genes each included one causal RV. Each gene contained 1–20 independent (A) or correlated (B) RVs.
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions

8. Figure 7
Distributions of the p Values from aSPUpath and GRASS and Their Comparison in the Log10 Scale for the WTCCC CD Data
Shown are aSPUpath (A) and GRASS (B) and comparison (C).
The American Journal of Human Genetics  , 86-98DOI: ( /j.ajhg )
Copyright © 2015 The American Society of Human Genetics Terms and Conditions