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Endothelial Nitric Oxide Synthase in Bicuspid Aortic Valve Disease

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Presentation on theme: "Endothelial Nitric Oxide Synthase in Bicuspid Aortic Valve Disease"— Presentation transcript:

1 Endothelial Nitric Oxide Synthase in Bicuspid Aortic Valve Disease
Diana Aicher, MD, Carmen Urbich, MD, Andreas Zeiher, PhD, Stefanie Dimmeler, PhD, Hans-Joachim Schäfers, PhD  The Annals of Thoracic Surgery  Volume 83, Issue 4, Pages (April 2007) DOI: /j.athoracsur Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Representative immunoblot of endothelial nitric oxide synthase (eNOS), tubulin, and platelet endothelial cell adhesion molecule −1 (PECAM-1) in bicuspid and tricuspid aortic valves. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Expression of eNOS (determined as ratio eNOS/PECAM-1/tubulin) in the aortic wall of patients with tricuspid and bicuspid aortic valves. (= one aortic wall sample; eNOS = endothelial nitric oxide synthase; PECAM-1 = platelet endothelial cell adhesion molecule −1.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Bicuspid aortic valve. Correlation between eNOS expression (determined as ratio eNOS/PECAM-1/tubulin) and maximum aortic diameter in bicuspid aortic valves. There was a significant correlation between eNOS expression and maximum aortic diameter (r = −0.530; p = 0.029). (• = one aortic wall sample; eNOS = endothelial nitric oxide synthase; PECAM-1 = platelet endothelial cell adhesion molecule −1.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Tricuspid aortic valves. The eNOS expression and maximum aortic diameter in tricuspid aortic valves. In patients with tricuspid aortic valves no correlation between aortic size and eNOS expression was found (maximum aortic diameter and eNOS: r = −0.093; p = 0.676). (• = one aortic wall sample; eNOS = endothelial nitric oxide synthase; PECAM-1 = platelet endothelial cell adhesion molecule −1.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

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