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Is parental consanguinity associated with reduced ovarian reserve?

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Presentation on theme: "Is parental consanguinity associated with reduced ovarian reserve?"— Presentation transcript:

1 Is parental consanguinity associated with reduced ovarian reserve?
Tanja Seher, Elisabeth Thiering, Majdah al Azemi, Joachim Heinrich, Carsten B. Schmidt-Weber, Coleen Kivlahan, Jan Gutermuth, Human M. Fatemi  Reproductive BioMedicine Online  Volume 31, Issue 3, Pages (September 2015) DOI: /j.rbmo Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 Significantly lower antral follicle count (AFC) in female offspring of consanguineous parents. Transvaginal ultrasound reveals significantly lower AFC (median = 7) in women descending from consanguineous marriages in comparison to women from non-consanguineous marriages (median = 11) (***P < ). Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Premenopausal antral follicle count (AFC) and anti-Müllerian hormone in young females descending from consanguineous unions. Physiological age-dependent decline of AFC in non-consanguineous patients, while consanguineous patients revealed AFC-concentrations that indicate low ovarian reserve at all ages examined (20–39 years). Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions


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