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Thomas F. Lindsay, MDCM, FRCS(C), Paul M

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1 Acute pulmonary injury in a model of ruptured abdominal aortic aneurysm 
Thomas F. Lindsay, MDCM, FRCS(C), Paul M. Walker, MD, FRCS(C), Alex Romaschin, PhD  Journal of Vascular Surgery  Volume 22, Issue 1, Pages 1-8 (July 1995) DOI: /S (95) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Lung permeability index in each of three separate experimental protocols is represented in this histogram. Sham, shock, and clamp controls are shown for each group. Shock of 1 or 2 hours duration or simulated infrarenal aneurysm repair did not alter lung permeability. One hour of supramesenteric clamping alone significantly increased lung permeability index (asterisk represents p < 0.05 vs sham, pound sign represents p < 0.05 vs shock). Combined events of shock and supramesenteric clamp (combined group) resulted in most significant increase in lung permeability index observed (double asterisk represents p < 0.05 vs clamp). Journal of Vascular Surgery  , 1-8DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Lung myeloperoxidase content was significantly elevated in the IR 2 combined and shock groups compared with shams (asterisk represents p < 0.05 vs sham). In SM 1 group combined group had significantly elevated amounts of MPO compared with sham and clamp (double asterisk represents p < 0.05). Journal of Vascular Surgery  , 1-8DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Blood pressure measurements in infrarenal group with 1 hour of hypotension. Note similar degrees of hypotension in shock and combined groups. Journal of Vascular Surgery  , 1-8DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Blood pressure measurements in IR 2 group. Only shock and combined data are shown for simplicity. In combined group, note transient decrease in blood pressure when clamps are removed, followed by rapid return toward shock-alone group. Journal of Vascular Surgery  , 1-8DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 Blood pressure measurements in supramesenteric group differs as supramesenteric clamping increases blood pressure more than infrarenal clamping, and final blood pressure is about 10 mm Hg lower than infrarenal clamping groups at conclusion of experiment. Journal of Vascular Surgery  , 1-8DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions


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