1. Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

2. Flow chart of inclusion and exclusion criteria
Exclusion criteria were assessed in the 2 years preceding the index date for the medication and in the 5 years preceding the index date for hospitalizations, diagnosis, or medical procedures
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

3. Characteristics of patients in the cohort starting a new statin treatment in the Quebec RAMQ database in 1999–2004
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

4. Characteristics of patients at the baseline with respect to the adherence level
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

5. Characteristics of patients and their matched controls having experienced a CAD
a P values are related to analyses made to compare cases with controls
b At treatment initiation
c Statin equivalent in simvastatin dose during follow-up. Simvastatin 20 mg = lovastatin 40 mg = pravastatin 40 mg = fluvastatin 80 mg =
atorvastatin 10 mg = rosuvastatin 5 mg
d Proportion of days covered (%)
e Diagnosis of cerebrovascular disease: (ICD-9 codes 430–438) or medical procedures
f Diagnosis of peripheral artery disease: diagnosis (ICD-9 codes 440–447), medical procedure of noncoronary angioplasty, or use of pentoxifylline
g Diagnosis of chronic heart failure: (ICD-9 codes: , , , , 428.0, 428.1, and 428.9) or a prescription of furosemide alone
or with digoxin, ACEI, spironolactone, or β-blockers
h Diagnosis of other CVD: arrhythmia: diagnosis (ICD-9 code 427), a medical procedure using a pacemaker, or use of drugs for cardiac
arrhythmias (amiodarone, digoxin, quinidine, disopyramide, flecainamide, mexiletine, procainamide, propafenone, or sotalol); or valvular heart
disease; or use of anticoagulants
i ICD-9 or pharmacologic treatment
j Proportion of days covered (%) in the year before the index date
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

6. Kaplan-Meier curves of the time to the first CAD
event among high and low adherence levels
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

7. Rate ratios (RR) and 95% confidence intervals of coronary artery disease
a Statin equivalent in simvastatin dose during follow-up. Simvastatin 20 mg = lovastatin 40 mg = pravastatin 40 mg = fluvastatin 80 mg =
atorvastatin 10 mg = rosuvastatin 5 mg
b Proportion of days covered (%)
c At treatment initiation
d Diagnosis of cerebrovascular disease: (ICD-9 codes 430–438) or medical procedures
e Diagnosis of peripheral artery disease: diagnosis (ICD-9 codes 440–447), medical procedure of noncoronary angioplasty, or use of pentoxifylline
f Diagnosis of chronic heart failure: (ICD-9 codes: , , , , 428.0, 428.1, and 428.9) or a prescription of furosemide alone
or with digoxin, ACEI, spironolactone, or β-blockers
g Diagnosis of other CVD: arrhythmia: diagnosis (ICD-9 code 427), a medical procedure using a pacemaker, or use of drugs for cardiac
arrhythmias (amiodarone, digoxin, quinidine, disopyramide, flecainamide, mexiletine, procainamide, propafenone, or sotalol); or valvular heart
disease; or use of anticoagulants
h ICD-9 or pharmacologic treatment
i Proportion of days covered (%) in the year before the index date
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]

8. Change in RR of CAD after adjustment for unmeasured confounders
Perreault S, et al. Eur J Clin Pharmacol 2009 Jun 16 [Epub]