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Tumor Response Kinetics after Schedule-Dependent Paclitaxel Chemoradiation Treatment for Inoperable Non-small Cell Lung Cancer: A Model for Low-Dose.

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Presentation on theme: "Tumor Response Kinetics after Schedule-Dependent Paclitaxel Chemoradiation Treatment for Inoperable Non-small Cell Lung Cancer: A Model for Low-Dose."— Presentation transcript:

1 Tumor Response Kinetics after Schedule-Dependent Paclitaxel Chemoradiation Treatment for Inoperable Non-small Cell Lung Cancer: A Model for Low-Dose Chemotherapy Radiosensitization  Hong Zhang, PhD, MD, Ollivier Hyrien, PhD, Kishan J. Pandya, MD, Peter C. Keng, PhD, Yuhchyau Chen, PhD, MD  Journal of Thoracic Oncology  Volume 3, Issue 6, Pages (June 2008) DOI: /JTO.0b013e dbe Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Example of CT images of one patient at various time points postchemoradiation. Tumor contours are demonstrated in the periphery of the lesions. T = 0 demonstrates a right upper lobe lesion before treatment. T = X mo demonstrates tumor contours at X months after completion of chemoradiation treatment. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e dbe) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Tumor volume changes in absolute cubic centimeters of each individual patient from before treatment (time = 0) to months after completion of chemoradiation treatment. Some patients had only one or 2 follow-up CTs post-treatment due to death from distant metastasis. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e dbe) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Statistical modeling of the tumor response kinetics of pulsed paclitaxel chemoradiation for inoperable NSCLC. The figure demonstrates various prediction limits for the tumor volume as a function of time computed by simulating the model up to 5 months. Estimates of the model parameters and their standard errors are shown in Table 2. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e dbe) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions


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