1. Figure 1

2. * A B * * *
Figure 2

3. A B * *
Figure 3

4. Luc activity fold inductionB C D
pENGluc
0,5 1
1,5 2
2,5 3
3,5 4
4,5
Raloxifene 0,2nM
Luc activity fold induction
pALK1luc 3 * *
2,5 2
Luc activity fold induction
1,5 1
0,5
Raloxifene 0,2nM
Figure 4

5. 0.2nM Raloxifene Figure 5 αSp1 αER αIgG Input
ChIP of Endoglin proximal promoter HUVECs
0.2nM Raloxifene
αSp1 αER αIgG Input
100 bp
200 bp
130 bp
Figure 5

6. CONTROL RALOXIFENE 0,2nM Figure 6 80 70 60 50 Network density 40 30 20
0.2nM Raloxifene 70 60 50
Network density 40 30 20 10
20h
Figure 6

7. Wound Healing Figure 7 Arbitrary Densitometer Units Time 100 80 60 40
control 20
0.2nM Raloxifene 0h
24h
30h
44h
Figure 7
Time