1. Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Nodule 
Andras Khoor, MD, Jeffrey L. Myers, MD, Henry D. Tazelaar, MD, Stephen J. Swensen, MD 
Mayo Clinic Proceedings 
Volume 76, Issue 2, Pages (February 2001)
DOI: /
Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions

2. Figure 1
Photomicrographs. Top, Low magnification demonstrating a solitary nodule of pulmonary Langerhans cell histiocytosis. The periphery of the nodule shows an irregular interface with the adjacent alveolated lung parenchyma. The central portion of the nodule reveals a combination of inflammation and fibrosis (hematoxylin-eosin, original magnification ×2). Bottom, Higher power shows a combination of inflammation and fibrosis with numerous darkly staining eosinophils and clusters of Langerhans cells with folded nuclei (arrows) (hematoxylin-eosin, original magnification ×200). Inset, These cells were positive for S-100 protein and CD1a (immunoperoxidase for CD1a, original magnification ×400).
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions