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Psoriasis Susceptibility Locus on 18p Revealed by Genome Scan in Finnish Families Not Associated with PSORS1  Kati Asumalahti, Tarja Laitinen, Päivi Lahermo,

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Presentation on theme: "Psoriasis Susceptibility Locus on 18p Revealed by Genome Scan in Finnish Families Not Associated with PSORS1  Kati Asumalahti, Tarja Laitinen, Päivi Lahermo,"— Presentation transcript:

1 Psoriasis Susceptibility Locus on 18p Revealed by Genome Scan in Finnish Families Not Associated with PSORS1  Kati Asumalahti, Tarja Laitinen, Päivi Lahermo, Sari Suomela, Raija Itkonen-Vatjus, Christer Jansen, Jaakko Karvonen, Seija-Liisa Karvonen, Timo Reunala, Erna Snellman, Tutta Uurasmaa, Ulpu Saarialho-Kere, Juha Kere  Journal of Investigative Dermatology  Volume 121, Issue 4, Pages (October 2003) DOI: /j x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Pedigree structures of the nine genome scan families. DNA samples from the numbered individuals were available in the analysis. Gray, uncertain diagnosis; coded as unknown in the analyses. Black dot, PSORS1-negative individuals. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Nonparametric linkage analysis results performed using GeneHunter.Solid lines, NPL curves (scale on the left y-axis); dotted lines, information content curves (scale on the right y-axis). The locations of PSORS1-7 loci are marked below curves. Dashed lines under figures, six fine mapping loci. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Nonparametric linkage analysis curve of the telomeric part of 18p (0–28 cM from telomere) after fine mapping. Fine mapping was performed in two stages. White arrowheads, markers used in the first fine mapping; black arrowheads, markers added in the second fine mapping. Unmarked markers were used in the original genomewide scan. Black box, the haplotype pattern mining haplotype (D18S471-AFM238yg3-D18S967); gray box, shared haplotype (D18S458-D18S471-AFM238yg3). Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions


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