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Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients  Sara Vicente-Muñoz, Ph.D., Inmaculada Morcillo,

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Presentation on theme: "Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients  Sara Vicente-Muñoz, Ph.D., Inmaculada Morcillo,"— Presentation transcript:

1 Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients  Sara Vicente-Muñoz, Ph.D., Inmaculada Morcillo, M.D., Leonor Puchades-Carrasco, Ph.D., Vicente Payá, M.D., Antonio Pellicer, M.D., Antonio Pineda-Lucena, Ph.D.  Fertility and Sterility  Volume 106, Issue 7, Pages e1 (December 2016) DOI: /j.fertnstert Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Representative 600-MHz 1H-nuclear magnetic resonance Carr-Purcell-Meiboom-Gill spin-echo pulse spectrum of a plasma sample from an endometriosis patient. (A) Full spectrum (δ 8.5–0.5 ppm); (B–D) Magnifications of spectra regions from 0.7–3.10 ppm, 3.20–5.40 ppm, and 6.90–8.50 ppm regions, respectively. Assigned metabolites: 1, lipoproteins: high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) (-CH3); 2, isoleucine; 3, leucine; 4, valine; 5, fucose; 6, 3-hydroxybutyrate; 7, lipoproteins: HDL, LDL, VLDL (-CH2)n; 8, lactate; 9, alanine; 10, fatty acids (-CH2-CH2CO); 11, lysine; 12, arginine; 13, acetate; 14, unsaturated fatty acids (-CH2-CH2-CH=CH-); 15, N-acetyl groups; 16, proline; 17, glutamine; 18, methionine; 19, fatty acids (-CH2-CH2CO); 20, acetoacetate; 21, citrate; 22, polyunsaturated fatty acids (-CH=CH-CH2-CH=CH-); 23, asparagine; 24, creatinine; 25, creatine; 26, choline-containing metabolites (choline, phosphocholine, glycerophosphocholine); 27, glucose; 28, trimethylamine-N-oxide; 29, myo-inositol; 30, glycerol; 31, serine; 32, choline; 33, threonine, 34, glycerophosphocholine; 35, glycerol of lypids; 36, fatty acids (-CH=CH-); 37, tyrosine; 38, histidine; 39, phenylalanine; 40, formate. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions


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