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R. U. Varier, E. Biltaji, K. J. Smith, M. S. Roberts, M. K. Jensen, J

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Presentation on theme: "R. U. Varier, E. Biltaji, K. J. Smith, M. S. Roberts, M. K. Jensen, J"— Presentation transcript:

1 Cost-effectiveness analysis of treatment strategies for initial Clostridium difficile infection 
R.U. Varier, E. Biltaji, K.J. Smith, M.S. Roberts, M.K. Jensen, J. LaFleur, R.E. Nelson  Clinical Microbiology and Infection  Volume 20, Issue 12, Pages (December 2014) DOI: / Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Model structure. FMT, faecal microbiota transplantation; RCDI, recurrent Clostridium difficile infection; AE, adverse effects of FMT. Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 (a, b, c) Results, one-way sensitivity analysis. (a) Impact of changes in cost of FMT on overall cost per strategy. (b) Impact of changes in probability of CDI cure with FMT on overall cost per strategy. (c) Impact of changes in probability of CDI cure with FMT on overall effectiveness per strategy. Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

4 FIG. 3 Tornado diagram, FMT vs. Metronidazole, ICER.
Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

5 FIG. 4 Cost-effectiveness acceptability curve. Depicts the probability that each of the three treatment strategies are cost-effective at different willingness-to-pay thresholds. Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions


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